Late G1 Cell Cycle Molecular Pathways
نویسندگان
چکیده
منابع مشابه
Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle.
The effect of quercetin, a flavonoid found in many plants, on the proliferation of human leukemic T-cells was analyzed. Quercetin reversibly blocked the cell cycle at a point 3-6 h before the start of DNA synthesis. Expression of the growth-related genes histone H4, cyclin A and B, and p34cdc2 was suppressed in cells blocked with quercetin. Comparison of the quercetin arrest points with those o...
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Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical in haemopoiesis. Recently we found that the Src family member Lyn is highly expressed in SCF-responsive cells, associates with c-Kit and is activated within minutes of the addition of SCF. Here we show that SCF activates Lyn a second time, hours later, during SCF-induced cell cycle progression. In cells arrested at ...
متن کامل[Involvement of Rho proteins in G1 phase cell cycle progression].
Rho proteins, including RhoA, Rac1 and Cdc42, are members of the Ras superfamily of monomeric GTP-binding proteins, which are well-known regulators of the cytoskeleton. Numerous studies have shown that an intact cytoskeleton is required for cell cycle progression through G1 phase as well as mitosis and cytokinesis. Because of their role in both cytoskeletal rearrangement and mitogenic signalin...
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ژورنال
عنوان ژورنال: MedEdPORTAL
سال: 2008
ISSN: 2374-8265
DOI: 10.15766/mep_2374-8265.1159